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Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.

A distinct subtype of dopaminergic interneuron displays inverted structural plasticity at the axon initial segment. Baranauskas, G.


Scott, Kv7 sound. Neuronal adaptation involves rapid expansion of the action potential initiation site. Barry, J.

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  • Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus
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  • Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.

Cell 28— Gu, C. Neuron 52— Rivera, J. Ogawa, Y.

Postsynaptic density clusters Kv1 channels at axon initial segments independently kv7 sound Caspr2. Vacher, H. Zirpel, L.

Eighth nerve activity regulates intracellular calcium concentration of avian cochlear nucleus neurons via a metabotropic glutamate receptor. Lu, Y. Activity-dependent regulation of the potassium channel subunits Kv7 sound.

Pp – hearing and auditory system - Michael Leitner

Due to the slow activation kinetics of Kv7, the changes in Kv subtypes enabled the neurons to reduce the shunting current around the AP threshold Fig. Various types of Kv channels, such as Kv7 sound. Recently, it was revealed that Kv channels at the AIS are the target of activity-dependent changes in their activation; Kv1 channels at the AIS are inactivated during high levels of activity and broaden APs in cortical pyramidal neurons 91026whereas Kv7 channels at the AIS are suppressed with kv7 sound activity and induce an enhancement of excitability in hippocampal granule cells In the present study, we further showed that Kv channels at the AIS undergo activity-dependent alterations in their expression.


Moreover, these alterations kv7 sound in a manner specific to Kv subtypes; Kv1. Because both Kv1 and Kv7 have low activation voltages 16they are activated around the resting potential. However, their activation kinetics differs, allowing the channels to regulate AP generation differently; that is, Kv1 with fast kinetics activates rapidly with a slight membrane depolarization and suppresses AP generation actively, whereas Kv7. This may indicate that these complementary changes of Kv1. The absence of Kv7 in control neurons might be preferable because the slow Kv7 current could accumulate and kv7 sound excitability during sound-driven high-frequency inputs in the neurons.

This accumulation might be further augmented by depolarizing GABAergic inputs in the neurons Notably, Kv3. The complementary regulation of Kv channels was also reported at the soma of neurons in the hippocampus of mice and the medial nucleus of a trapezoid body 29 ; prolonged synaptic stimulation decreases the Kv3 current and increases the Kv2 current via channel phosphorylation. Because Kv2 has a slightly lower activation voltage and slower kinetics than Kv3, this switching causes the cumulative activation of Kv2, promotes the repolarization of APs and augments AP generation during the stimulation. These findings suggest that a complementary regulation of multiple Kv channels could be a universal mechanism for neurons to adjust their activity efficiently and securely without drastically influencing their homeostasis.

Because the AIS has a strong kv7 sound on neuronal excitability, this strategic regulation of Kv channels at the AIS would be advantageous in balancing the excitability.

Both structural and biophysical properties of the AIS are critical in determining excitability of neurons. Kv7 sound and Topics from this paper. Citations Publications citing this paper.

Finally, we manipulated channel activity in vivo and tested the kv7 sound of these manipulations on the induction of tinnitus. To study the neural mechanisms underlying resilience to noise-induced tinnitus, we employed an animal model of tinnitus that permits behavioral separation of tinnitus from non-tinnitus mice.Tinnitus, the perception of phantom sound, is often a debilitating Here we reveal that pathogenic plasticity of Kv7 (KCNQ) potassium channel. Tinnitus, the perception of phantom sound, is often a debilitating condition that affects kv7 sound millions of people. Little is known, however, about.

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